An unemployed, divorced father accepts a job as a night watchman in the Museum of Natural History in New York, where he learns that the exhibits come to life.
The magic bringing ancient figures and creatures to life is in peril, and Larry must unite his historic friends and new heroes to stop it from running out.
A single mother and her two children move to a new town and learn that they have a connection to the original Ghostbusters, and they discover a secret legacy.
A biochemist with a rare blood disease tries to cure himself, and though it seems he succeeds initially, he ends up infecting himself with a form of vampirism.