The ladies grow concerned after discovering Rose has fallen in love with a diminutive suitor; Sophia must leave town to attend her grandson's graduation.
A influenza outbreak threatens to prevent Rose, Dorothy and Rose from attending a high-profile charity banquet, and Sophia wants to find a date for that night.
Blanche goes into a deep depression when her doctor tells her she is starting to go through menopause; Dorothy, Rose and Sophia become business partners.
Dorothy, Rose and Blanche are given the opportunity to attend a movie premiere, but they are mistakenly arrested for solicitation on the way to the venue.
Rose undergoes an extreme personality change after claiming she died and came back to life after a throat spasm, but her new persona annoys her housemates.
Sophia learns her new best friend's illness may cause him to forget they have ever met; Rose's beloved teddy bear is accidentally sold at Blanche's garage sale.
Blanche's smooth-talking new beau appears to be interested in Sophia as well; Rose becomes Dorothy's student on her way to earn her high school diploma.
Dorothy, Rose and Blanche feel Sophia isn't enjoying life, unaware that her day includes a grocery store clash, volunteering and conducting a jazz band.
Rose will spend three days waiting for the results of an AIDS test after receiving questionable blood during a transfusion after her gall bladder surgery.
Blanche is shocked to discover that her late husband is alive and well having faked his death nine years ago to avoid a jail sentence; Dorothy's love triangle.
Blanche's brother Clayton arrives in Miami with the revelation that he is planning a commitment ceremony for him and his partner; Rose is up for an award.
Blanche reconsiders her feelings for commitment-free sex after her casual partner fails to answer the phone; Rose pursues her dream of becoming a TV reporter.
Sophia learns her new best friend's illness may cause him to forget they have ever met; Rose's beloved teddy bear is accidentally sold at Blanche's garage sale.