TV Guide Oxygen Wednesday

When a rebellious teenager disappears, a search turns up clues that lead investigators on a hunt for a killer, and forensic evidence will reveal the truth.

While vacationing in Florida, a mother and her two daughters disappear and are later found dead in Tampa Bay, leaving no evidence behind until five years later.

When four teenagers are murdered in an otherwise peaceful suburban town, their killings go unsolved for three years until a composite sketch sparks new leads.

After a young college student's death is ruled a homicide, police immediately suspect the victim's boyfriend, but DNA points them in a different direction.

Despite a man's claim to have accidentally shot himself, authorities uncover a different story at a crime scene, where a love triangle is beginning to unfold.

Authorities believe a relapse into drugs is the cause behind a mother's disappearance, but her family and friends suspect foul play.

Officers investigate after armed intruders break into a family's home, and they discover that someone in the family was hiding a secret.

Officers investigate after armed intruders break into a family's home, and they discover that someone in the family was hiding a secret.

Secret agents organize a bold undercover operation years after a journalist was first kidnapped and tortured while on an assignment overseas.

The largest case of serial killers in California's history that begins with Paul Cosner vanishing in 1984.

After 12 years have passed since Natalee Holloway's disappearance, her father Dave Holloway gets a new, vital lead, but he is suspicious of the source.

Dave and a team of investigators delve into a covert operation with a goal to obtain a taped confession and evidence that could convict Natalee's killer.

In New Orleans, tensions are high as the investigative team begins running out of time to obtain the necessary information from a co-conspirator.

TJ and his team visit Aruba to try and obtain DNA evidence from Natalee's alleged burial site; Dave attempts to vonicne his informant to go the extra mile.

TJ rushes to the site where the co-conspirator claims he exhumed Natalee's remains; the team looks for DNA evidence that could lead to convictions.

After following a lead for two years, the investigators have enough evidence that could finally answer the 12-year-old mystery of what happened to Natalee.

A new look is taken at the disappearance of two African American twins from Georgia in 1990 by a former federal prosecutor and homicide detective.

One man believed to have found his calling in the military, but one night, after building a thriving career and family, the father of five gets gunned down.

A young woman with big dreams is found murdered, and investigators wonder if she was the victim of a robbery gone wrong or personal crime.

When three children arrive home to discover that their mother is missing, police begin searching for the woman, with only blood traces as evidence of a crime.

A woman who always put her children first vanishes without a word and leaves her loved ones panicking, but investigators uncover dark secrets.

After a college student is stabbed to death, investigators work to narrow down their list of suspects to one name and unravel the mystery.

A young woman eager to make her mark on the world disappears, and investigators thought they found a motive after learning about a love triangle.

Two high school sweethearts were celebrating their anniversary before their evening turned deadly, and investigators must uncover the secrets of an illusion.

A woman devoted to her faith and five children found herself starting her life over after a divorce, but an investigation reveals secrets after she is murdered.

When a dangerous fire tears through a family home, a mystery is unearthed in the ashes, leading investigators to believe that what happened was not an accident.

After a missing woman's body is found close to her apartment, the police try to untangle a confusing web of lies to find evidence no one was supposed to see.

After a pregnant woman is shot and killed while on her way to work, her sisters investigate the crime as amateur detectives and discover a secret.

After a pregnant woman is shot and killed while on her way to work, her sisters investigate the crime as amateur detectives and discover a secret.