The Professor decides to invent a new, one-way time machine, which inevitably takes the crew further into the future, where they have no hope of returning.
Peter Parker has everything he wants, including Mary Jane and the life of a superhero, but his life becomes dark when a substance attaches itself to him.
When Louise admits that she has never felt scared before, the family goes to a haunted house in an effort to change that, but mayhem ensues after their visit.
Bob goes to pick up Gayle so she does not miss the Thanksgiving celebration, but gets caught in a snowstorm coming back, leaving Linda to prepare the turkey.
Bob hosts a dinner party and tries to bond with his new friend, but Gayle uses the occasion to introduce her new romantic interest, who has a past with Louise.
Meg takes an internship to work for Tom Tucker but ends up with Neil as her partner and kisses him during a life-threatening situation that is caught on tape.
Peter receives slavery reparations from Lois's father after discovering an African-American ancestor while teaching Chris about the Griffin's Irish heritage.
The Professor develops a revolutionary new invention which allows people to exchange brains, leading him and Amy to swap minds as a part of an agreement.