Roseanne discovers that David is living with Darlene in Chicago and heads off to confront them; Dan and Roseanne talk to Mark about returning to Becky.
Fran agrees to cover for Maggie as a candy striper at the hospital, but she is mistaken for a nurse and is ordered to shave Maxwell before his appendectomy.
After a conversation with a fellow nanny who is retiring and has few prospects, Fran begins to worry about her future; Niles gives C.C. a birthday gift.
Jonathan tries to get Jason's dad Miki to get to know his son a little bit better, but the man struggles to cope with the fact that his son has cancer.
Malcolm and Ashley break up after Cindy, a beautiful bandleader, manages to find a way to come between the couple; Malcolm is disillusioned over the split.
Niles learns that Maris has not been faithful to him as a result of a woman who calls into Frasier's show, and he challenges the man she's with to a duel.
Jackie and Roseanne are shocked by Bev's announcement that she will be moving to Lanford; Jackie feels embarrassed when she begins dating a younger man.
George and Angie decide that their spending habits have gotten out of control, so they place a bet to determine which of them is able to live most frugally.
The Lopez family contemplates putting Needles to sleep when they learn that he has a tumor; George and Max make extravagant promises while praying for the dog.
George is left in charge of the kids when Angie is away on business; when Carmen and Max misbehave, George sends them to Benny's house for the weekend.
Complications arise at a gay bar when Nancy's new girlfriend kisses Roseanne; one of Becky's old boyfriends shows up to give Mark a reason to distrust her.
Fran's pen pal asks to meet her in person after years of correspondence, which makes Fran anxious due to the amount of exaggeration contained in her letters.
Abishola worries about her humble Nigerian roots after she spends a day of luxury with the girls; Goodwin learns that Kofo is getting a pitch meeting with Bob.