A group of misogynist terrorists take over a train destined for Washington D.C., but they're no match for Roseanne and her family, who happen to be aboard.
The Conners come to realize that money can't buy happiness when their first Thanksgiving as a wealthy family is ruined by Dan's absence and Bev's revelation.
Jackie forces Dan to reveal news of his affair to Roseanne; D.J. wants to videotape Darlene giving birth; Jackie must face the truth about her love life.
C.C. attempts to prove that she is as fun and nurturing as Fran by taking the children out for a day of fun, but the experience results in Grace running away.
Rumors begin to circulate about Bob and Abishola possibly trying to have a baby and expectations from their friends and family begin to wear the couple down.
After a terminally ill child decides to look after a troubled boy, Jonathan gives advice to the young runaway and a widow about her fatally sick child.
Jonathan and Mark get jobs working in a local area boxing ring and the owner's grandson has a good opportunity at winning the local championship fight.
In response to Nicolette's requests, Malcolm and Eddie decide to host a ladies' night at the club, complete with male exotic dancers for their enjoyment.
Niles' nerves get the best of him as he's preparing to ask Daphne out, but she overhears him discussing the love of his life and asks who the mystery woman is.
Frasier is being stretched in different directions as he is supposed to attend a surprise party, a Safari Club meeting, and have a date all in one evening.
Dan becomes distraught at his father after learning that he lied to him about his mother's mental condition until Roseanne decides to step in and console him.
Darlene figures out that D.J. has begun going to church after his school day, as he gives a lecture to Roseanne about morals after an incident at the diner.
Bev decides to return back to the house after claiming she broke her pelvis at the retirement home due to Dan's failure to safe-proof the shower in her room.
Fred gathers the courage to propose to Jackie and takes advice from Roseanne on the best way to ask the question and gathers tips from her favorite soap opera.
George accidentally throws out Angie's only mementos of her deceased grandmother; George's father dies before George has the opportunity to give him a kidney.
Carrie gets neurotic when put in charge of a group of "misfits" at night which makes Doug lonely, but he finds that Arthur makes an acceptable replacement.
Doug and Carrie bump into Father McAndrew and are shamed into attending church services, meanwhile, unbeknownst to anyone, Arthur puts the house up for sale.
Carrie sends Doug to a therapist regarding his overeating, and he shows promise so Carrie asks the therapist to "help" with other issues behind Doug's back.
Roseanne's family and friends try to pick her spirits up after she locks herself in her room and finally try an intervention in a final ditch effort to help.
Maxwell must miss Christmas with his family; Fran buys the children expensive gifts only to learn that her Christmas bonus is not what she had imagined.
Maxwell's former nanny arrives for a visit and makes changes to the children's behavior, forcing them to all dress alike and putting them on strict schedules.
Bob begins to rethink his decision to sell the company just as a new offer arrives; Abishola struggles with whether they should flaunt their new wealth.