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The Substance

Horror Science Fiction ★ 7.1

When a celebrity feels that her career is hitting a roadblock due to her age, she begins to use an illegal drug that temporarily alters her physical appearance.

Today · Friday, 26 June 1 airing

06:16

HBO 2

Friday, 3 July 2026 1 airing

04:48

HBO

Cast

Demi Moore

Elisabeth

Margaret Qualley

Sue

Dennis Quaid

Harvey

Edward Hamilton-Clark

Fred

Gore Abrams

Oliver

Oscar Lesage

Troy

Christian Erickson

Man at Diner

Robin Greer

Male Nurse

Tom Morton

Doctor

Hugo Diego Garcia

Diego - Boyfriend

Daniel Knight

Casting Director

Jonathon Carley

Assistant Casting Director

Jiselle Henderkott

Girl Auditioning / New Year's Eve Show Dancer

Akil Wingate

TV Host

Vincent Colombe

Man in Suit #1 - Harvey's Office